Gtn 5 minute: Glyceryl trinitrate (GTN): used to treat angina (chest pain) and anal fissures

Glyceryl Trinitrate 5 mg/ml Sterile Concentrate — Summary of Product Characteristics (SmPC)

This information is intended for use by health professionals

Glyceryl Trinitrate 5 mg/ml Sterile Concentrate.

1 ml of solution contains 5 mg of glyceryl trinitrate. Each 5 ml and 10 ml ampoules contains 25 mg and 50 mg glyceryl trinitrate respectively.

Excipients with known effect

Glyceryl Trinitrate 5 mg/ml Sterile Concentrate contains 2639.2 mg anhydrous ethanol in each 5 ml ampoule and 5278.4 mg anhydrous ethanol in each 10 ml ampoule which is equivalent to 527.84 mg/ml (52.78% w/v).

This product also contains 223.6 mg propylene glycol in each 5 ml ampoule and 447.2 mg propylene glycol in each 10 ml ampoule which is equivalent to 44.72 mg/ml.

For the full list of excipients, see section 6.1.

Concentrate for solution for infusion.

Clear, practically colourless solution.

Surgery: Glyceryl trinitrate is indicated for:

1. the rapid control of hypertension during cardiac surgery.

2. reducing blood pressure and maintaining controlled hypotension during surgical procedures.

3. controlling myocardial ischaemia during and after cardiovascular surgery.

Unresponsive Congestive Heart Failure: Glyceryl trinitrate may be used to treat unresponsive congestive heart failure secondary to acute myocardial infarction.

Unstable Angina: Glyceryl trinitrate may be used to treat unstable angina that is refractory to treatment with beta-blockers and sublingual nitrates.

Posology

The posology of intravenous glyceryl trinitrate should be adjusted to achieve the desired clinical response.

Adults

The dose of glyceryl trinitrate should be adjusted to meet the individual needs of the patient. The recommended dose range is 10-200 microgram/min, although up to 400 microgram/min may be necessary during some surgical procedures.

Paediatric population

The use of glyceryl trinitrate in children is not recommended, as the safety and efficacy of glyceryl trinitrate has not yet been established in this population.

Elderly population

There is no evidence that a posology adjustment is required in the elderly.

Hepatic/renal impairment

Additional dose adjustments in patients with severe hepatic insufficiency or severe renal failure may be necessary and require additional monitoring.

Surgery

A starting dose of 25 microgram/min is recommended for the control of hypertension, or to produce hypotension during surgery. This may be increased by increments of 25 microgram/min at 5 minute intervals until the blood pressure is stabilised. Doses between 10-200 microgram/min are usually sufficient during surgery, although doses of up to 400 microgram/min have been required in some cases. The treatment of perioperative myocardial ischaemia may be started with a dose of 15-20 microgram/min, with subsequent increments of 10-15 microgram/min until the required effect is obtained.

Unresponsive congestive heart failure

The recommended starting dose is 20-25 microgram/min. This may be decreased to 10 microgram/min, or increased in steps of 20-25 microgram/min every 15-30 minutes until the desired effect is achieved.

Unstable angina

An initial dose of 10 microgram/min is recommended with increments of 10 microgram/min being made at approximately 30 minute intervals according to the needs of the patient.

Method of administration

Not to be given by bolus injection.

Glyceryl Trinitrate Sterile Concentrate is a concentrated, potent drug which must be diluted in Dextrose (5%) Injection BP or Sodium Chloride (0.9%) Injection BP prior to its infusion.

Glyceryl Trinitrate Sterile Concentrate must be mixed under aseptic conditions immediately after opening.

Prepared admixtures should be given by intravenous infusion or with the aid of a syringe pump to ensure a constant rate of infusion. For an example of an admixture preparation, see section 6.6.

During administration of glyceryl trinitrate there should be close haemodynamic monitoring of the patient.

For full details it is advisable to consult the following dosage chart.

Infusion Rate (ml/hour or microdrops/min)	Dosage (micrograms/min) by concentration of admixture
	100 micrograms/ml	200 micrograms/ml	300 micrograms/ml	400 micrograms/ml
	(1 x 10 ml ampoule in 500 ml)	(2 x 10 ml ampoules in 500 ml)	(3 x 10 ml ampoules in 500 ml)	(4 x 10 ml ampoules in 500 ml)
	(2 x 5 ml ampoule in 500ml)	(4 x 5 ml ampoule in 500ml)	(6 x 5 ml ampoule in 500ml)	(8 x 5 ml ampoule in 500ml)
6 12 18 24 30 36 42 48 54 60 66 72 78 84 90	10 20 30 40 50 60 70 80 90 100 110 120 130 140 150	20 40 60 80 100 120 140 160 180 200 220 240 260 280 300	30 60 90 120 150 180 210 240 270 300 330 360 390 420 450	40 80 120 160 200 240 280 320 360 400 440 480 520 560 600

1 ml = 60 paediatric microdrops = 20 standard drops

To those who have or are:

1. Hypersensitive to glyceryl trinitrate and nitrates or to any of the excipients listed in section 6.1

2. Hypotensive shock or uncorrected hypovolaemia

3. Increased intracranial pressure

4. Constrictive pericarditis and pericardial tamponade

5. Severe anaemia and arterial hypoxaemia

6. Taking sildenafil (Viagra) or other phosphodiesterase inhibitors used for the treatment of erectile dysfunction or pulmonary arterial hypertension (see section 4.5)

7. Cerebral haemorrhage

8. Angina caused by hypertrophic obstructive cardiomyopathy

9. Concomitant administration of a soluble guanylate cyclase (GC) stimulator, such as riociguat due to potentiation of hypotensive effects (see section 4.5).

Not to be given by bolus injection.

Glyceryl Trinitrate Sterile Concentrate contains propylene glycol which can lead to hyperosmolality, haemolysis, and lactic acidosis. It is recommended that the use of this preparation be restricted to not more than three successive days.

Glyceryl Trinitrate Sterile Concentrate should not be administered to patients known to be hypersensitive to organic nitrates, nor should it be given to patients with uncorrected hypovolaemia, severe anaemia or cerebral haemorrhage or hypotension.

Glyceryl trinitrate should be used with caution in patients presenting with malnutrition, hypothyroidism, severe hypothermia, or severe impairment of hepatic and/or renal function.

Severe hypotension may occur with even small doses of Glyceryl trinitrate.

Evidence is not available to demonstrate the safety of glyceryl trinitrate for intracoronary injection.

Glyceryl Trinitrate Sterile Concentrate should be used with caution in patients predisposed to closed angle glaucoma.

Excipient Information

Glyceryl Trinitrate Sterile Concentrate contains propylene glycol and ethanol (see section 2).

Each 5 ml ampoule of Glyceryl Trinitrate Sterile Concentrate contains 2639.2 mg of anhydrous ethanol, which is equivalent to less than 66 ml of beer or 27 ml of wine. Each 10 ml ampoule of Glyceryl Trinitrate Concentrate contains 5278.4 mg of anhydrous ethanol which is equivalent to less than 132 ml of beer or 53 ml of wine. Administration of a 10 ml ampoule of Glyceryl Trinitrate Sterile Concentrate over 125 min (i.e. at an infusion rate of 400 microgram/min that is higher than normally recommended but may be necessary during some surgical procedures, see section 4.2) to an adult weighing 70 kg would result in exposure to 75.4 mg/kg of ethanol which may cause a rise in blood alcohol concentration (BAC) of about 12.6 mg/100 ml. For comparison, for an adult drinking a glass of wine or 500 ml of beer, the BAC is likely to be about 50 mg/100 ml. Co-administration with medicines containing e.g. propylene glycol or ethanol may lead to accumulation of ethanol and induce adverse effects, particularly in young children with low or immature metabolic capacity. The ethanol content in this preparation is likely to affect children and neonates. These effects may include somnolence and changes in behaviour. The ethanol may also affect their ability to concentrate and take part in physical activities.

The ethanol content in this medicinal product should be carefully considered in the following patient groups who may be at higher risk of ethanol-related adverse effects:

• Pregnant or breast-feeding women (see section 4.6)

• Patients with liver disease

• Patients with epilepsy.

• Patients suffering from alcoholism.

The amount of ethanol in this medicinal product may impair the ability to drive or use machines (see section 4.7). The amount of ethanol in this medicinal product may alter the effects of other medicines. The effects of ethanol may be reduced when the dose is administered more slowly using an infusion rate of 10-200 microgram/min (see section 4.2).

A 24 hour infusion of Glyceryl Trinitrate Sterile Concentrate at the maximum recommended infusion rate of 200 microgram/min administered to an adult weighing 70 kg would result in a propylene glycol exposure of 36. 8 mg/kg/day. A propylene glycol exposure of ≥50 mg/kg/day might result in case of a 24 hour infusion at an infusion rate that is higher than the maximum recommended infusion rate (e.g. 300 microgram/min) or administration to a lower weight patient (e.g. 50 kg adult). Medical monitoring, including measurement of the osmolar and/or anion gap, is required in patients with impaired renal and/or hepatic function who receive ≥50 mg/kg/day of propylene glycol. Various adverse effects attributed to propylene glycol have been reported, such as renal dysfunction (acute tubular necrosis), acute renal failure and liver dysfunction. Prolonged administration of propylene glycol-containing products, as well as co-administration with other substrates of alcohol dehydrogenase (e.g. ethanol), increase the risk of propylene glycol accumulation and toxicity, especially in patients with liver or kidney impairment. Propylene glycol doses of ≥1 mg/kg/day may induce serious adverse effects in neonates, while doses of ≥50 mg/kg/day may induce adverse effects in children less than 5 years old. Administration of ≥50 mg/kg/day of propylene glycol to pregnant or lactating women should only be considered on a case by case basis (see section 4.6).

Phosphodiesterase inhibitors

Sildenafil (Viagra) and other phosphodiesterase inhibitors has known effects on the nitric oxide/cGMP pathway, and has been shown to potentiate the hypotensive effects of nitrates such as Glyceryl Trinitrate Sterile Concentrate. A severe and possibly dangerous fall in blood pressure may occur. This can result in collapse, unconsciousness and may be fatal. Such use, therefore, is contraindicated. If a patient treated with these drugs for erectile dysfunction or pulmonary arterial hypertension needs a rapidly effective nitrate, he/she should be closely monitored (see section 4.3).

Hypotensive Agents and Tricyclic Anti-depressants

Glyceryl trinitrate may potentiate the action of other hypotensive drugs, and the hypotensive and anticholinergic effects of tricyclic anti-depressants.

Soluble guanylate cyclase (GC) stimulators

Concurrent use of Glyceryl trinitrate and a soluble guanylate cyclase stimulator such as riociguat is contraindicated due to potentiation of hypotensive effects (see section 4.3).

Heparin

Glyceryl trinitrate may interfere with the anticoagulant effect of heparin and can induce heparin resistance.

Analgesics

Glyceryl trinitrate may slow the metabolism of morphine-like analgesics.

Pregnancy

The safety of glyceryl trinitrate during pregnancy has not been demonstrated and therefore it should not be used unless considered essential by the physician.

The ethanol and propylene glycol content of Glyceryl Trinitrate Sterile Concentrate should be taken into account for pregnant women (see section 4.4). Propylene glycol has not been shown to cause reproductive or developmental toxicity in animals or humans, however, it may reach the foetus. Administration of ≥50 mg/kg/day propylene glycol to pregnant women should only be considered on a case by case basis.

Breast-feeding

The safety of glyceryl trinitrate during lactation has not been demonstrated and therefore it should not be used unless considered essential by the physician.

The ethanol and propylene glycol content of Glyceryl Trinitrate Sterile Concentrate should be taken into account in women who are breast-feeding (see section 4.4). Propylene glycol has not been shown to cause reproductive or developmental toxicity in animals or humans, however, it has been found in milk and may be orally absorbed by a nursing infant. Administration of ≥50 mg/kg/day propylene glycol to lactating women should only be considered on a case by case basis.

There is no information available regarding the effects of glyceryl trinitrate on the ability to drive and operate machinery. Patients should refrain from driving or using machines until they know that the medicinal product does not negatively affect these abilities.

The amount of ethanol in Glyceryl Trinitrate may impair the ability to drive or use machines (see section 4. 4).

Undesirable effects frequencies are defined as: very common (≥1/10), common (≥1/100 <1/10), uncommon (≥1/1,000 <1/100), rare (≥1/10,000 <1/1,000) or very rare (<1/10,000), not known (cannot be estimated from the available data).

During administration of Glyceryl Trinitrate Sterile Concentrate, the following undesirable effects may be observed:

Nervous system disorders
Very common		Headache
Common		Dizziness (including dizziness postural), somnolence
Cardiac disorders
Common		Tachycardia
Uncommon		Enhanced angina pectoris symptoms
Not known		Bradycardia, palpitations
Vascular disorders:
Common		Orthostatic hypotension
Uncommon		Circulatory collapse (sometimes accompanied by bradyarrhythmia and syncope).
Not known		Hypotension, flushing
Gastrointestinal disorders:
Uncommon		Nausea, vomiting
Very rare		Heartburn
Skin and subcutaneous tissue disorders:
Uncommon	Allergic skin reactions (e.g. rash), allergic contact dermatitis
Not known	Dermatitis exfoliative, rash generalised
General disorders and administration site conditions
Common		Asthenia
Uncommon		Pruritus, burning, erythema and irritation
Investigations
Not known		Heart rate increase

Severe hypotensive responses have been reported for organic nitrates and include nausea, vomiting, restlessness, pallor, and excessive perspiration.

During treatment with Glyceryl Trinitrate Sterile Concentrate, a temporary hypoxemia may occur due to a relative redistribution of the blood flow in hypoventilated alveolar areas. Particularly in patients with coronary artery disease this may lead to a myocardial hypoxia

Reporting of suspected adverse reactions

Reporting suspected adverse reactions after authorisation of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions via the Yellow Card Scheme at: www.mhra.gov.uk/yellowcard or search for MHRA Yellow Card in the Google Play or Apple App Store.

Signs and Symptoms

Overdosage usually results in hypotension and tachycardia.

Vomiting, restlessness, syncope, cyanosis, coldness of the skin, impairment of respiration, bradycardia, psychosis and methaemoglobinaemia may also occur.

Treatment

The symptoms may be readily reversed by discontinuing treatment; if hypotension persists, raising the foot of the bed or compression bandaging of the patient’s legs and the use of vasoconstrictors such as intravenous methoxamine or phenylephrine are recommended.

Methaemoglobinaemia should be treated by intravenous methylene blue. Oxygen and assisted respiration may be required.

ATC-code: C01DA02

Glyceryl trinitrate, an organic nitrate, is a vasodilator. The principal pharmacological action of glyceryl trinitrate is the relaxation of vascular smooth muscle. Glyceryl trinitrate produces, in a dose-related manner, dilation of both arterial and venous beds. Dilatation of the post-capillary vessels, including large veins, promotes peripheral pooling of blood and decreases venous return to the heart, reducing left ventricular end-diastolic pressure (pre-load).

Arteriolar relaxation reduces systemic vascular resistance and arterial pressure (after-load). Myocardial oxygen consumption or demand (as measured by the pressure-rate product, tension time index and stroke work index) is decreased by both arterial and venous effects of glyceryl trinitrate, and a more favourable supply demand ratio can be achieved.

Therapeutic doses of intravenous glyceryl trinitrate reduce systolic, diastolic and mean arterial blood pressure. Effective coronary perfusion pressure is usually maintained, but can be compromised if blood pressure falls excessively or increased heart rate decreases diastolic filling time.

Glyceryl trinitrate reduces elevated central venous and pulmonary capillary wedge pressures, pulmonary vascular resistance and systemic vascular resistance. Heart rate is usually slightly increased, presumably a reflex response to the fall in blood pressure. Cardiac index may be increased, decreased or unchanged.

Patients with elevated left ventricular filling pressure and systemic vascular resistance values in conjunction with a depressed cardiac index are likely to experience an improvement in cardiac index. Alternatively, when filling pressures and cardiac index are normal, cardiac index may be slightly reduced by intravenous glyceryl trinitrate.

Glyceryl trinitrate is widely distributed in the body with an apparent volume of distribution of 200 L in adult male subjects, and is rapidly metabolised to dinitrates and mononitrates, with a short half-life estimated at 1-4 minutes. This results in a low plasma concentration after intravenous infusion. Glyceryl trinitrate is also well absorbed from the gastro-intestinal tract, but it is not known if it is distributed into milk.

At plasma concentrations of between 50 and 500 ng/ml, the binding of glyceryl trinitrate to plasma proteins is approximately 60% and 30% respectively. The plasma half-life of glyceryl trinitrate is about 1-4 minutes. Glyceryl mononitrate which is inactive, is the principal metabolite.

Not applicable.

Ethanol

Propylene glycol (E1529)

Water for injections

Glyceryl Trinitrate Sterile Concentrate is incompatible with polyvinylchloride (PVC) and severe losses of glyceryl trinitrate (over 40%) may occur if this material is used. Contact with polyvinylchloride bags should be avoided. Polyurethane also induces a loss of the active ingredient. No other drug should be admixed with this medicinal product.

3 years.

Prior to first use: Do not store above 25°C. Keep the ampoules in the outer carton in order to protect from light.

Open ampoules of glyceryl trinitrate should be used immediately and any unused portion discarded.

In use:

Following dilution in either 0.9% sodium chloride or 5% dextrose injection solutions in glass containers, chemical and physical in-use stability has been demonstrated for 7 days at both 18°C and 4°C.

Following dilution in 5% dextrose solution in polycarbonate or polypropylene syringes at concentrations of 1 mg or 4 mg per ml protected from light, chemical and physical in-use stability has been demonstrated for 72 hours at room temperature.

However, from a microbiological point of view, the product should be used immediately. If not used immediately, in-use storage times and conditions prior to use are the responsibility of the user and would normally not be longer than 24 hours at 2-8°C, unless dilution has taken place in controlled and validated aseptic conditions.

Do not use if the solution is discoloured.

Clear, Type I glass ampoules – 5 ml and 10 ml in packs of 5 ampoules.

Not all pack sizes may be marketed.

Glyceryl Trinitrate Sterile Concentrate is a concentrated, potent drug which must be diluted in Dextrose (5%) Injection BP or Sodium Chloride (0.9%) Injection BP prior to its infusion.

Glyceryl Trinitrate Sterile Concentrate must be mixed under aseptic conditions immediately after opening.

Admixtures are prepared by replacing a given volume of infusion vehicle with an equal volume of the product to produce the final infusion solution. For admixture storage, refer to section 6.4.

Example of admixture preparation

To obtain an admixture of glyceryl trinitrate at a concentration of 100 micrograms/ml add 10 ml (containing 50 mg glyceryl trinitrate) to 490 ml of infusion vehicle to give a final volume of 500 ml.

A dosage of 100 micrograms/min can be obtained by giving 60 ml of this admixture per hour. This is equivalent to a drip rate of 20 standard drops per minute or 60 paediatric microdrops per minute. At this drip rate the mixture provides enough solution for an infusion time of 8 hours 20 minutes.

Compatible with commonly employed infusion solutions, Sodium Chloride (0.9%) Injection and Dextrose (5%) Injection.

Compatible with glass infusion bottles and rigid infusion packs made of polyethylene.

For single use only.

Any unused medicinal product or waste material should be disposed of in accordance with local requirements.

Hospira UK Limited

Horizon

Honey Lane

Hurley

Maidenhead

SL6 6RJ

PL 04515/0006

Date of latest renewal: 21 December 1995

01/2022

Ref gxGY 5_1

Withdrawal of intravenous glyceryl trinitrate: absence of rebound phenomena with transition to oral isosorbide dinitrate

Clinical Trial

. 2005 Apr;32(4):269-72.

doi: 10.1111/j.1440-1681.2005.04182.x.

Elizabeth A Kelly¹, Rebekah M Ahmed, John D Horowitz

Affiliations

Affiliation

¹ The Queen Elizabeth Hospital, Department of Medicine, University of Adelaide, South Australia, Australia.

PMID:

15810990
DOI:

10.1111/j.1440-1681.2005.04182.x

Clinical Trial

Elizabeth A Kelly et al.

Clin Exp Pharmacol Physiol.

2005 Apr.

. 2005 Apr;32(4):269-72.

doi: 10.1111/j.1440-1681.2005.04182.x.

Authors

Elizabeth A Kelly¹, Rebekah M Ahmed, John D Horowitz

Affiliation

¹ The Queen Elizabeth Hospital, Department of Medicine, University of Adelaide, South Australia, Australia.

PMID:

15810990
DOI:

10.1111/j.1440-1681.2005.04182.x

Abstract

1. Glyceryl trinitrate (GTN) is frequently infused intravenously as a component of the management of acute coronary syndromes (ACS). Abrupt cessation of GTN infusion after periods of more than 24 h administration often induces rebound vasoconstriction reflecting ‘pseudotolerance’; this is also the basis of the ‘zero hour phenomenon’ during chronic nitrate therapy. The efficacy of oral nitrate regimens to prevent vasoconstriction following cessation of intravenous GTN has not been previously examined. Therefore, we investigated the effects of transition from intravenous GTN to oral isosorbide dinitrate (ISDN) on a parameter of apparent arterial stiffness in patients with ACS. 2. The effects of GTN infusion at 5 microg/min on augmentation index (AIx) were quantified in patients (n = 10) with stable angina pectoris in order to establish the magnitude of effect on apparent arterial stiffness. 3. This infusion rate of GTN reduced AIx from 23 +/- 10% (SD) to 3 +/- 14% (SD) (P < 0.01). The effect of transition from GTN infusion of greater than 24 h duration to ISDN (10 mg tds) were examined in patients (n = 16) with ACS (unstable angina/non-Q-wave myocardial infarction). No patient developed recurrent angina during the 24 h following cessation of GTN infusion. The level of AIx was 8 +/- 4% (SD) prior to GTN cessation and fell to 5 +/- 6% (SD) on ISDN (P = 0.05). 4. Thus, in patients treated for ACS, transition from intravenous GTN to low dose oral ISDN is associated with an incremental vasodilatation and no evidence of ‘rebound’ ischaemia.

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Rauf & Faik — 5 minutes lyrics Rauf & Faik

View all lyrics Rauf & Faik

Five more minutes talking to you
I don’t know what to do
I don’t know what to do
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I don’t know what to do
I don’t know what to do

Five more minutes, I’ll talk to you
I don’t know what to do
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You understood
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That our love will never stop blooming
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You said
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I will never forget yours

Five minutes left
Say you’re in love
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Tell me you’re in love

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I don’t know what to do
I don’t know what to do
Five more minutes and I’ll break up with you
I don’t know what to do
I don’t know what to do

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Rauf & Faik — «I love you» (2018)

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Rauf & Faik
5 minutes (Rauf and Faik)

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Six months after the conclusion of the contract with 1C, Rarus sold 50 1C: Accounting units per month and became the fastest growing partner of 1C.

Now the 1C-Rarus partner network is 3,500 IT companies in 270 cities! Software distribution is a separate partnership philosophy and an opportunity for joint development of a large number of IT companies.

The first industry solution «1C-Rarus: Catering»

The 1C industry business started in the restaurant of the golf club on Rublevsky Highway. Dima Kazachkov came to the talks and realized that all restaurants have the same problems, which the circulation software product will help to solve.

In the photo: the first package of the 1C-Rarus: Public Catering program.

The first edition of Alfa-Auto

Graduates and honors students of the Zhukovsky Academy Zubkov Alexey and Gavrilov Vladimir released the first mass-production product for the auto business. Today, Alfa-Auto is the undisputed leader in the auto business automation market and occupies 60% of the market. In 20196th edition of Alfa-Avto was published.

The department of corporate projects «1C-Rarus» was created

Work with corporate clients is becoming a strategic direction of the company’s development. Therefore, a department of corporate projects is being created, which has grown into a directorate with a territorially distributed structure in 16 cities. The level of technology development allows you to conduct projects anywhere in the world. At the same time, more than 500 specialists are doing 100 projects and 200 corporate clients are regularly supported.

The first branch was opened in Nizhny Novgorod

In 1999, the total staff of the company «1C-Rarus» amounted to 120 people. And today, only 100 employees work in the Nizhny Novgorod office, more than 500 attestation certificates of the 1C company speak of their professionalism. During its work, the company has released solutions «1C: Accounting for a poultry farm» and «1C: Management of a poultry farm».

In the photo: Nizhny Novgorod branch of 1C-Rarus in 2019.

The development department «1C-Rarus» was created

The 1C-Rarus development department has been separated into a separate department. Now the department employs 200 developers on the 1C platform and other platforms.

1C-Rarus received the ISO 9001:1999 certificate

With the beginning of regional expansion, we are introducing a reliable tool that guarantees customers the level of quality of services provided by 1C-Rarus in different cities. This tool is the ISO certificate. Already 19For years in a row, the entire 1C-Rarus group of companies has been annually audited to evaluate the effectiveness of work performed on the 1C platform.

1C-Rarus:Assistance affiliate program launched

The company is launching a marketing program for partners to promote industry solutions. We train partners and compensate for advertising and training costs. We also hold many traveling seminars in different cities to popularize industry automation.

In the photo: Dmitry Kazachkov in Ulyanovsk at the first road show.

1C:CRM direction is open

The CRM for 1C:Enterprise project is successfully launched. Today, the 1C:CRM solution line is used in 32 business sectors and offers advanced marketing and sales technologies. For small companies, there is the possibility of free use of the program in the 1C: Fresh cloud!

The direction of automation of retail trade grew by 2 times

Retail Automation showed a 2-fold growth over the past 2 years. 1C-Rarus, together with 1C and Euroset, is holding the first large-scale press conference at Izvestia Publishing House dedicated to the automation of the largest market player.

In the photo (from left to right): Dmitry Kazachkov (1C-Rarus), Boris Nuraliev (1C), Eldar Razroev (Euroset).

20,000 industry customers have chosen 1C-Rarus solutions

2005 — the rapid growth of industry automation. 1C-Rarus offers circulation solutions for 20 business sectors. The customer votes with a ruble for technologies and products of 1C and 1C-Rarus.

Received 6 awards from associations and media in 2006

The company receives recognition not only within the 1C network, but also confirms its leadership with independent awards and prizes:

«Golden Merchant-2006» in the nomination «Software products for automating retail chains».
«Golden scales. Restaurant-2006».
Public award «Russian Trade Olympus» in the nomination «For the best comprehensive support of business processes of a trading enterprise».
«Golden Scales-2006».
Diploma of the 7th International Forum of Accountants and Auditors — «The best company on the Russian market of software products in the field of accounting, taxation and audit».
Golden Crane» in the nomination «For the introduction of new technologies in the restaurant business».

Branch
opened in St. Petersburg

With the advent of an office in St. Petersburg, the number of branches increased to 4. Today, the office occupies a leading position in the automation market of the North-West. The number of its employees in 2019 is 150 people, and the level of their professionalism is confirmed by 850 certificates of the 1C company.
The branch specializes in the areas of integrated automation, implementation, maintenance and customer support on the basis of subscription agreements.

A branch was opened in Kazan

1C-Rarus entered the market of Tatarstan by opening a branch in Kazan on the basis of AVS-Technology in 2008. Today, the Kazan office occupies a leading position among 1C partners in the region. The company’s clients: PJSC Tatneft, Management Company LLC TMS Group, PJSC KVZ and large enterprises of Tatarstan. More than 200 specialists work in the Kazan branch.

1C-Business Architect is part of 1C‑Rarus Group of Companies

1C-Business Architect is a member of the 1C-Rarus group of companies. Now it is the largest and leading partner of 1C in the industry. Employees of the company received more than 2,500 1C certificates and published more than 30,000 implemented solutions for clients.

«1C-Rarus» automates the network of coffee shops «Shokoladnitsa»

In 1999, the Shokoladnitsa chain of coffee houses chose the 1C-Rarus: Restaurant Management standard solution as an accounting system. And for 10 years now he has been a client of 1C-Rarus. Now the chain of coffee houses «Shokoladnitsa» also uses an innovative product — «1C: Catering. Module for 1C:ERP».

1C-Rarus becomes a partner of the Adizes Institute

1C-Rarus starts a consulting project on organizational changes based on the Adizes methodology, and subsequently the cooperation grew into a long-term partnership. 1C-Rarus, together with the Adizes Institute, has released the Adizes Executive Dashboard software product. In the photo: Dmitry Kazachkov (1C-Rarus), Yitzhak Adizes and Tatyana Tyatina (1C-Rarus).

Pilot Group of Companies and 1C-Rarus signed an agreement on the merger of companies

Pilot Group and 1C-Rarus entered into a strategic agreement to merge the businesses of companies involved in the distribution of software and related products.

A branch was opened in Novosibirsk

By the end of 2011, the number of branches of the company grew to 7, and the staff amounted to more than 1,770 employees. The Novosibirsk office was formed on the basis of the Center for Consulting and Information Systems, which is part of the F1 group of companies and Sirint, the leading franchisee of 1C in Novosibirsk. Today, the branch employs 200 specialists.

1C-Rarus is the best supplier of MTS

Employees of 1C-Rarus regularly receive letters of thanks from customers. Some clients are quite small, and some are significant for the entire Russian economy, like MTS and BeeLine. We try to help all our clients, so for 28 years we have received about 50,000 letters of thanks.

Branch opened in Samara

Samara became the 8th branch of the company, and the total staff of 1C-Rarus grew to 2,000 employees. The Samara branch was founded on the basis of the official partner of 1C — Implosion SOFT. The office includes 60 employees and has its own Training Center. The clients of the branch in Samara are more than 2,000 companies, including BC Eurasia, Volgaburmash, Rusfinance Bank, Trade House LUKOIL.

1C-Rarus starts rendering services in the cloud

For 7 years of work, 1C-Rarus has created its own infrastructure and grown the direction from «0» to 14,000 users, who are offered 70 programs.

Created a direction for mobile development

The 1C-Rarus mobile development department has grown from the startup Mobile Application for Personal Finance. Now 4 mobile applications are being released that are used by > 3 million people in the world — BOSS, Budget, Fitness, Diet.

1C-Rarus starts cooperation with LLC Tatneft-Neftekhim

In 2013, OAO TATNEFT began commercial operation of the ERP system, which covered 800 jobs. Modern technologies help Tatneft-Neftekhim effectively manage its production, which produces 12 million tires per year, and regular deliveries of finished products to 80 countries around the world. Assistance in the implementation of the project was provided by specialists from 1C Rarus.

1C-Rarus in Moscow moves to a new office

Today, the company’s central office is located at 9B Dmitrovskoye Shosse, within walking distance from the Timiryazevskaya metro station and the main office of 1C.

Branch
opened in Voronezh

1C-Rarus opens a branch in Voronezh on the basis of Portal-S. The branch’s clients are Voronezh enterprises: Khmelnik LLC, Vodmashoborudovanie plant OJSC, KVANT-TELECOM CJSC, Direct Logistics LLC.

Alfa-Auto solution implemented at VOLVO

The Swedish company Volvo has been using the Alfa-Auto program in its work for more than 10 years. Now 1C-Rarus provides technical support to the Volvo dealer network. We thank Volvo for appreciating our work!

Branch
opened in Rostov-on-Don

In 2015, the Rostov office «1C-Rarus» was created on the basis of the official partner of «1C» — the company «Celesta». Today, the branch has more than 500 clients, including such large enterprises as the construction company SK 10GPZ, Neis-Yug LLC, NAIS LLC, Lege Artis Eye Polyclinic LLC. The branch has experience in automating motor transport enterprises, wholesale and retail companies and manufacturing enterprises.

Learn.rarus.ru educational project launched

«1C-Rarus» opened a training center for partners «1C». Now there are 65 courses and hundreds of specialists from partner companies who improve their skills every day.

1C-Rarus has created a new accounting system for Tele2

1C-Rarus standardized the work of Tele2 mono-brand retail throughout Russia and consolidated sales information in one information system.

Branch
opened in Yoshkar-Ola

The branch of 1C-Rarus in Yoshkar-Ola was founded in 2016 on the basis of the official partner of the 1C franchisee, the Avtor company, formerly part of the VDGB group of companies, which has been operating in the field of information technology since 1995. The company specializes in complex automation of management, workflow and interdepartmental electronic interaction.

Branch
opened in Chelyabinsk

The branch «1C-Rarus» in Chelyabinsk was created on the basis of the company VC «SoftService», the official partner of the company «1C» since 2002. The office in Chelyabinsk has 100 employees, more than 1,000 clients, including large holdings that are part of the RBC TOP 500: “GRC im. Makeev, Trubodetal, Mechel, Uralvagonzavod and other large corporate clients.

1C-Rarus confirmed the quality certificate 9001:2015

1C-Rarus has a high reputation as a reliable partner in the 1C community and among customers. The quality management system has been in operation at 1C-Rarus since 2001 and is certified in accordance with ISO 9001:2015.

XV anniversary conference for partners in Greece

Unique conferences are held annually for 1C-Rarus clients and partners, which are rated by the participants at least 4. 8 points on a 5-point scale. We get high marks due to a balanced program: business part, active rest and an individual approach to each participant.

1C-Rarus automated 1,500 Beeline stores

In just 4 months, 1C-Rarus deployed the Beeline information system for 4,000 simultaneously working workstations with the possibility of further scaling. The project received the «1C: Project of the Year» award as the best geographically distributed project!

Leader of the «1C: Project of the Year 2017» contest — 9 projects!

Our projects were highly appreciated by the 1C community. 1C:Project of the Year status was given to: Avtovaz, GKNPTs named after M.-V.-Khrunichev, REP-Holding, Volgaburmash, Akron, Atomstroykompleks, Ferronordic, OZNA , Research Institute «Carbamide», Pharmacy network of the Novosibirsk region.

Opened representative office in Vietnam

1C-Rarus opened a representative office in Vietnam.

1C-RarusTechDay — a conference for 1C specialists

1C-Rarus is a leading partner of 1C in technologies and development tools. In 2019, we shared our technologies for the first time. More than 350 programmers came to the conference in Skolkovo. According to surveys of participants, 90% consider the conference successful and useful, and 75% of participants will come to the conference next year. Thank you!

1C-Rarus in the rating of the largest retail IT suppliers

Analytical publishing house CNews Analytics and TAdviser portal made up the ratings of «Largest IT vendors in retail» for 2018-19gg. In independent research, 1C-Rarus occupies a leading position. The growth of the 1C-Rarus retail business was 23.4%, which is 2. 5 times higher than the market average.

1C-Rarus prepared the winner of the WorldSkills 2019 championship

1C programmers successfully performed at the international championship of professionals WorldSkills Kazan 2019. Among the finalists and prize-winners is Aigul Sultanova (student of the Kazan College of Information Technologies), who was trained by Alexander Lukanov, an expert in the development of 1C-Rarus, for a year.

Electronic deliveries of industry solutions

Remote sales and service 1C-Rarus, together with 1C, supports all operating industries with the help of electronic deliveries and licenses for industry solutions. Sales, installation, configuration, training and maintenance — we will do all this remotely.

Released a new product «1C-Rarus: Financial Management 3»

The product allows you to keep records and prepare financial statements for separate enterprises, holdings, conglomerates and groups of companies.

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